Precision Medicine RFP's
The Vagelos Precision Medicine supplemental funding for mouse models is made possible by the generous gift of Roy and Diana Vagelos, to the Columbia Precision Medicine Initiative, and it is intended to support ground-breaking research in the field of precision medicine.
Proposals are requested to generate new mouse models of disease, discovered by human sequencing, primarily in constitutional genetics, not alterations in neoplasms. This program will only subsidize new projects, and not retroactively fund or supplement projects that have already begun. Funds will be awarded to subsidize costs of mouse mutant strain design and construction (e.g. by CRISPR) from approved service providers. The subsidy will be up to 66% of the total quoted cost per mutant strain, or up to $15,000 per mutant strain, whichever is less.
The development of approximately 20 models will be supported in the first year. A maximum of two models per request per investigator will be permitted.
Eligibility: Applicants must have a full-time Columbia University faculty appointment (including NYPSI and clinical faculty) at the rank of an Assistant, Associate, or Full Professor.
Application Directions: Prepare description (2-page maximum) for each model as follows:
- Investigator name, home department, contact information
- Project title
- Description of human mutation and mouse orthologue to be targeted
- How the mutation was selected and the basis for disease involvement
- Relevance to investigator research interests and to precision medicine
- Describe the way the mice will be studied
- Any other information that would shed light on the likelihood of success
Provide the following supporting information:
- Obtain design, prices, model development updates and timelines from service providers (quotes not required for application, but funds will not be released until quote is received)
- Work with Institute for Comparative Medicine to ensure approval of purchase orders and eventual delivery of mice into a CU vivarium (Business manager: Seth Mayersohn sm3580; Veterinary services - Andrea Hubbard ah2911)
- Review checklist points 1 through 7 below
Applications will be examined by the review committee, headed by Program Directors: Wayne Frankel, PhD and Ali Gharavi, MD, on a rolling basis with notification of funding within a month of review.
Submit application by March 30th 2018, as one single pdf, to the Program Administrator at email@example.com
1. Does the mouse carrying the mutation already exist? What is known about its viability, transmission and availability? Example websites to check:
2. Type of mutation desired (more complex models will cost more)
- Simple null allele (knockout)
- Conditional knockout (lox p sites flanking exon)
- Simple knockin (point mutation(s) only)
- Complex knockin
- Site-specific reporter or cre gene insertion
- Conditional point mutation (e.g. flox-stop cassette)
3. Mouse strain background (e.g. C57BL/6J, 129/SvImJ, FVB/NJ): Are you targeting in direct zygotes or in ES cells? Some vendors may not be licensed to legally target certain mouse strains or sub-strains from other vendors. Check with your service provider on strains they use.
4. “All in” service (from initial design to receipt of proven carriers), or participate in the screening for, and development of, the mutation? Some vendors will only offer all-in service, which may be more expensive but gives the convenience of proven germline transmission and fecundity and viability of mice carrying the mutation; Others may offer a la carte services that will save out of pocket-costs but do not do the screening and initial breeding.
5. Do you already have a IACUC protocol for studying mice? Ensure the expected mice are on your protocol and funding is in place for animal housing, in synchrony with the estimated delivery date
6. We strongly recommend that you have funds to cryopreserve the strain, or have that included as an integral part of the quotation (if it is offered by the same service provider). CPMI will not pay for separate cryopreservation or for storage costs).
7. PI must have their service provider approved by ICM as a mouse vendor - this program will not pay for quarantine or re-derivation services. Please note Columbia purchasing may require sole source justification. Examples of service providers that offer mouse gene targeting (may not be approved by CU and the ICM)
- HICCC Transgenic Core (Columbia – in ICRC)
- The Jackson Laboratory
- MSKCC Mouse Genetics Core
The Vagelos Precision Medicine Pilot Grant program is made possible by the generous gift of Roy and Diana Vagelos, to the Columbia Precision Medicine Initiative, and is intended to support ground-breaking research in the field of precision medicine.
Proposals are requested for two-year pilot studies in precision medicine. Awardees will receive $100,000 per year for two years. Studies must be relevant to advancing precision medicine basic science. Examples areas include genomic data, biomarkers, clinical data, new methods of working with precision medicine data, technology development, disease mechanism studies and stem cell biology. For research with human subjects, an IRB must be in place at the time of funding.
These pilot grants are intended to support feasibility studies that will establish a basis for applying for further research funding. As such, pilot grants are intended to generate preliminary data required to produce competitive grant applications to outside funders.
Three studies will be funded, with additional calls for proposals expected next year.
Eligibility: Applicants must have a full-time Columbia University faculty appointment at the rank of an Assistant, Associate, or Full Professor, including NYPSI and clinical faculty. Studies may involve more than one department, including collaboration between Morningside and Medical Center campuses. Preference will be given to applications including junior investigators. Applicants may apply for the Irving Institute Precision Medicine award and the Vagelos award, but may not hold both concurrently; if successful in both applicants will be able to choose their preferred award.
Budget: $100,000 per fiscal year for two years. Second year funding contingent on satisfactory progress report
Application Directions: Prepare detailed project description (2-4 page excluding references, minimum 11-point font) as follows:
• Background and Specific Aims
• Preliminary Findings
• Future Plans and Direction
• Literature citations
Provide the following supporting documents:
• Statement of Facilities and other Resources
• NIH-style biographical sketch for each investigator (5-page limit)
Submit documents by December 11th 2017, preferably as one single pdf to firstname.lastname@example.org
Eligible applications submitted by the deadline will be evaluated by confidential peer reviewers. Reviewers must remain anonymous but may opt to give feedback to the applicants through the Precision Medicine office, but are not required to do so. Winning applications will be announced in February 2018.
Questions? Email email@example.com
Irving Institute for Clinical and Translational Research
The Precision Medicine Research Fellowship aims to create the next generation of leaders in the development and application of Precision Medicine science and methods to improve public health. This new research fellowship in precision medicine will train physicians/researchers as Postdoctoral Research Scientists to use genomics and complex clinical data to improve clinical care and clinical outcomes by tailoring prevention, screening, and medical interventions based upon individual patient characteristics.
Applicants must have a PhD, MD, DDS, or comparable doctoral degree from an accredited domestic or foreign institution.
Duration: 2 years
Award Amount: $200,000 ($100,000 per year)
Quantity: Up to 2 per year
Application Deadline: 5:00pm EDT, Friday, May 18, 2018
Start Date: July 1, 2018
Visit here for more information and to download an application.
Accelerating Discoveries Toward Better Health