Funding Opportunities

Precision Medicine RFP's

Request for Proposals

Roy and Diana Vagelos Precision Medicine Basic Science Award

Irving Institute for Clinical and Translational Research Precision Medicine Award

The Herbert Irving Comprehensive Cancer Center Precision Medicine Award

Proposals are requested for one-year pilot studies in precision medicine. Studies must be relevant to advancing precision medicine basic science, pre-clinical/clinical approaches to tailoring medical care (prevention, diagnosis, and/or treatment) to the individual patient, and/or precision cancer research.

Example areas include, but are not limited to, disease mechanism studies, stem cell biology, genomic data, biomarkers, aggregated clinical/environmental data and/or patient-reported data to develop personalized medical care, decision support tools, new methods of working with precision medicine data and its integration with electronic health records, and new individualized approaches to effectively educate and communicate with patients.

These pilot grants are intended to support feasibility studies that will establish a basis for applying for further research funding. As such, pilot grants are intended to generate preliminary data required to produce competitive grant applications to outside funders.  

Up to five studies in total will be funded.

The Vagelos Precision Medicine Pilot Grant program is made possible by the generous gift of Roy and Diana Vagelos to the Columbia Precision Medicine Initiative (CPMI) and is intended to support ground-breaking basic research in the field of precision medicine. Precision Medicine Resource of the Irving Institute for Clinical and Translational Research (IICTR) seeks to facilitate research studies to improve diagnosis and treatment of disease, and ultimately improve maintenance of health through more accurate prediction of disease risk. The Herbert Irving Comprehensive Cancer Center (HICCC) is dedicated to understanding the biology of cancer and to applying that knowledge to the design of cancer therapies and prevention strategies.

Eligibility: Applicants must have a full-time Columbia University faculty appointment at the rank of an Assistant, Associate, or Full Professor. Preference will be given to proposals from early career investigators. Studies may involve more than one department, including collaboration between Morningside, Manhattanville, and Irving Medical Center campuses. Applications with an interdisciplinary and collaborative approach with other departments or schools will be viewed favorably. Each team is limited to six (6) members.

Budget: $100,000 per fiscal year.

Funding:The Vagelos Precision Medicine Pilot Grant program will provide funding for a one-year pilot grant of up $100,000 based on the project’s needs. Funding should be directed to specific experimental activities that will establish the basis for applying for further research funding from outside entities, i.e. government, foundations, and industry. We encourage that the majority of funds be utilized for project-specific study experiments, a smaller portion of the funds may be used towards post-doctorate researcher, graduate student, and technician salary. Funding may not be used towards PI salary.

Duration: 1 year.

NOTE: Projects involving human subjects and/or vertebrate animal research are conditionally selected for funding until IRB and/or IACUC approval is received. IRB/IACUC approval is not required at the time of application, but submission for approval must be completed within thirty (30) days of notification of potential funding. NIH-NCATS prior approval might also be required. NIH-NCATS prior approval documentation must be submitted to administrators of co-sponsoring institutions within seventy five (75) days of notification of potential funding.

Application Directions: Prepare detailed project description (4 page maximum excluding references, minimum 11 point Arial font) as follows:

• Background and Specific Aims – Page 1

• Preliminary Findings and Innovation – Page 2

• Methods – Pages 3 and 4 (1st half)

• Future Plans and Direction – Page 4 (2nd half)

• Literature citations

 

Provide the following supporting documents:

• List of Investigators;

• Synopsis of Proposal;

• List of current and pending sources of research funding;

• Budget and detailed budget justification;

• NIH-style biographical sketch for each investigator (5-page limit, including Other Support);

• Statement of Facilities and other Resources.

Submit documents by 11:59 PM ET on Friday, November 29th, 2019, via this link:

https://columbiaprecisionmed.smapply.io

Co-investigators, grant managers, and other personnel assisting with the application process can be granted access to the application by the Principal Investigator via the “Collaborators” feature on the Application Form page of the SMApply portal.

Senior leaders of the Columbia Precision Medicine Initiative, executive leaders of the Irving Institute, and directors of the Cancer Center may be consulted during the preparation of the application, but they should not be included as co-investigators or consultants on the application.

For a list of these individuals please visit:

https://precisionmedicine.columbia.edu/node/7

https://www.irvinginstitute.columbia.edu/about-us/message-director

https://cancer.columbia.edu/message-chairman

Eligible applications submitted by the deadline will be evaluated by confidential peer reviewers and Precision Medicine Executive Committee. Reviewers must remain anonymous but may opt to give feedback to the applicants through the Precision Medicine program, but are not required to do so. Winning applications will be announced in Spring 2020. 

For any questions about the application process, please email precisionmedicine@columbia.edu.

For any questions about the scientific content and eligibility, please contact:

Basic/fundamental precision medicine research

Dr. Melanie Brazil

Chief of Staff

Columbia Precision Medicine Initiative

mb4072@cumc.columbia.edu

Pre-clinical and clinical precision medicine research

Dr. Alex Fedotov

Senior Program Manager

Irving Institute for Clinical and Translational Research

avf2117@cumc.columbia.edu

Cancer precision medicine research

Dr. Tanisha Jackson

Senior Research Program Manager

Herbert Irving Comprehensive Cancer Center

tj2325@cumc.columbia.edu

The Vagelos Precision Medicine supplemental funding for mouse models is made possible by the generous gift of Roy and Diana Vagelos, to the Columbia Precision Medicine Initiative, and it is intended to support ground-breaking research in the field of precision medicine.

Proposals are requested to generate new mouse models of disease based on likely causal variants discovered by human sequencing, primarily in constitutional genetics, not alterations in neoplasms. The program will only subsidize new projects, and not retroactively fund or supplement projects that have already begun. Funds will be awarded to subsidize costs of mouse mutant strain design and construction from approved service providers. The subsidy will provide 2/3 of the total quoted cost per model, with the balance provided by the PI.

A maximum of two models per request per investigator will be permitted.  Funding for approximately 8-10 new models is anticipated in this review cycle.

Eligibility: Applicants must have a full-time Columbia University faculty appointment (including NYPSI and clinical faculty) at the rank of an Assistant, Associate, or Full Professor.

Application Directions: Prepare description (2-page maximum) for each model as follows. (Those applying for 2 models in separate genes should submit a separate application for each).

  • Investigator name, home department, contact information
  • Project title
  • Description of human mutation and mouse orthologue to be targeted
  • How the mutation was selected and the basis for disease involvement
  • Relevance to investigator research interests and to precision medicine
  • Describe the way the mice will be studied
  • Any other information that would shed light on the likelihood of success

Provide the following supporting information:

  • Provide the cost, the approach to model design and development, including milestones and timelines from a service provider of the applicant’s choosing. Formal quotes are encouraged but not required upon proposal submission.  However, funds will not be released until a formal quote is provided.
  • Work with Institute for Comparative Medicine to ensure approval of purchase orders and eventual delivery of mice into a CU vivarium (Business manager: Seth Mayersohn sm3580; Veterinary services - Andrea Hubbard ah2911)
  • Review checklist points 1 through 7 (next page)

Submit each application by January 30th, 2019, via the Columbia Precision Medicine Initiative grants management website: https://columbiaprecisionmed.smapply.io/.

Applications will be examined by a review committee, headed by Program Directors: Wayne Frankel, PhD and Ali Gharavi, MD, with notification of funding in April, 2019. Any questions may be sent to precisionmedicine@columbia.edu

Checklist

1. Does a mouse carrying the mutation, or one very similar to it, already exist?  What is known about viability, transmission and availability?  Example websites to check:

2. Consider the type of mutation desired (N.b.: more complex models may cost more)

  • Simple null allele (knockout)
    • Conditional knockout (e.g. lox-p sites flanking exon)
  • Simple knockin (point mutations)
    • Complex knockin (e.g. humanization of whole exons or genes)
    • Conditional knockin (e.g. flox-stop cassette or inverted exon)

3. Mouse strain background (e.g. C57BL/6J, 129/SvImJ, FVB/NJ): Are you targeting in direct zygotes or in ES cells? Some commercial vendors may not be licensed to target certain mouse strains or sub-strains from other vendors.  Check with your service provider.

4. Will you need “all in” service (from project design to receipt of proven carriers), or do you plan to participate in the screening for, and development of, the mutant line? Some vendors will only offer all-in service, which may be more expensive but may provide conveniences such as proven germline transmission, robust validation of the desired sequence without undesired contaminating mutations, and fecundity and viability of mice carrying the mutation. Some may offer a la carte service that saves out of pocket-cost, but not screening and initial breeding.

5. Do you already have an IACUC protocol? Ensure the expected mice are on your protocol and funding is in place for animal housing, in synchrony with the estimated delivery date

6. We strongly recommend that you have funds to cryopreserve the strain, or have that included as an integral part of the quotation (if offered by the same service provider). CPMI will not pay for separate cryopreservation or for storage costs).

7. PI must make sure the service provider is likely to be approved by ICM as a source - this program will not pay for quarantine or re-derivation services. Also note that Columbia Purchasing may require either sole source justification or competing quotes. Examples of commercial or local academic service providers that may offer mouse gene targeting include:

  • Columbia HICCC Transgenic Core
  • The Jackson Laboratory
  • Charles River Laboratories
  • Bioincyte
  • Cyagen
  • genOway
  • Ingenious
  • Leveragen
  • Miramus
  • MSKCC Mouse Genetics Core

Roy and Diana Vagelos Precision Medicine Pilot Grant

The Vagelos Precision Medicine Pilot Grant program is made possible by the generous gift of Roy and Diana Vagelos, to the Columbia Precision Medicine Initiative, and is intended to support ground-breaking basic research in the field of precision medicine.

Proposals are requested for two-year pilot studies in precision medicine. Studies must be relevant to advancing precision medicine basic science. Examples areas include genomic data, biomarkers, clinical data, new methods of working with precision medicine data, disease mechanism studies and stem cell biology. For research with human subjects, an IRB must be in place at the time of funding.

These pilot grants are intended to support feasibility studies that will establish a basis for applying for further research funding. As such, pilot grants are intended to generate preliminary data required to produce competitive grant applications to outside funders.  

Three studies will be funded.

Eligibility: Applicants must have a full-time Columbia University faculty appointment at the rank of an Assistant, Associate, or Full Professor. Studies may involve more than one department, including collaboration between Morningside, Manhattanville and Medical Center campuses. Preference will be given to applications including junior investigators. Each applicant may only be PI on one application per cycle. Multiple applications from the same PI will not be accepted. Applicants may apply for the Irving Institute Precision Medicine pilot award and the Vagelos award, but may not hold both concurrently; if successful in both applicants will be able to choose their preferred award.

Budget: $100,000 per fiscal year for two years. Second year funding contingent on satisfactory progress report

Application: Completed applications are due by Monday, October 15th 2018. Please submit your applications here.

 

Application Directions: Prepare detailed project descriptions as follows to be entered into the grant management system here. Word limits for each are provided within the grant management system for your convenience.

• Investigators

• Background and Specific Aims

• Preliminary Findings

• Methods

• Future Plans and Direction

• Literature citations

Provide the following supporting documents:

• Statement of Facilities and other Resources

• NIH-style biographical sketch for each investigator

• Budget


Eligible applications submitted by the deadline of October 15, 2018 will be evaluated by confidential peer reviewers and Precision Medicine Executive Committee. Reviewers must remain anonymous but may opt to give feedback to the applicants through the Precision Medicine office, but are not required to do so. Winning applications will be announced in January 2019. Awards will begin in spring 2019. 

Questions? Email precisionmedicine@columbia.edu

The Precision Medicine Junior Faculty and Post-Doctoral travel for child care subsidy program is funded through the Columbia Precision Medicine Initiative. This program assists scholars to attend conferences in the field of Precision Medicine by subsidizing travel costs associated with child care. Examples of child care costs include: Care giver to accompany you and your child; On-site childcare at the conference; Purchase of a ticket for e.g. a grandparent to come to your home, or to the conference, for childcare. The cost of regular day care or pre school at home is not a qualifying expense.

One of Columbia University’s core values is to expand scholarship, while increasing inclusion and success of highly qualified candidates. This program aims to expose future leaders in precision medicine to current leaders in the field. Scholars will increase their visibility and gain access to senior worldwide faculty in precision medicine.

Eligibility: Columbia Junior Faculty; Columbia post-doc with 2 years’ experience.

Budget: up to $600 per award

Application:

  • Personal Statement (250 words): Why is your chosen conference important in your field? How would you benefit from this scholarship?
  • Explanation for budget required

Submit your application here.

Deadline: Rolling

Factors for evaluation:

  • Relevance of conference to PM intellectual themes
  • Personal statement
  • Publication record
  • Possibility of a speaking role at the conference

 

If there are more qualified applications than awards available, applications will be entered into a lottery.

Questions? Email precisionmedicine@columbia.edu

The Vagelos Precision Medicine supplemental funding for mouse models is made possible by the generous gift of Roy and Diana Vagelos, to the Columbia Precision Medicine Initiative, and it is intended to support ground-breaking research in the field of precision medicine.

Proposals are requested to generate new mouse models of disease, discovered by human sequencing, primarily in constitutional genetics, not alterations in neoplasms. This program will only subsidize new projects, and not retroactively fund or supplement projects that have already begun. Funds will be awarded to subsidize costs of mouse mutant strain design and construction (e.g. by CRISPR) from approved service providers. The subsidy will be up to 66% of the total quoted cost per mutant strain, or up to $15,000 per mutant strain, whichever is less.

The development of approximately 20 models will be supported in the first year. A maximum of two models per request per investigator will be permitted.

Eligibility: Applicants must have a full-time Columbia University faculty appointment (including NYPSI and clinical faculty) at the rank of an Assistant, Associate, or Full Professor.

Application Directions: Prepare description (2-page maximum) for each model as follows:

  • Investigator name, home department, contact information
  • Project title
  • Description of human mutation and mouse orthologue to be targeted
  • How the mutation was selected and the basis for disease involvement
  • Relevance to investigator research interests and to precision medicine
  • Describe the way the mice will be studied
  • Any other information that would shed light on the likelihood of success

Provide the following supporting information:

  • Obtain design, prices, model development updates and timelines from service providers (quotes not required for application, but funds will not be released until quote is received)
  • Work with Institute for Comparative Medicine to ensure approval of purchase orders and eventual delivery of mice into a CU vivarium (Business manager: Seth Mayersohn sm3580; Veterinary services - Andrea Hubbard ah2911)
  • Review checklist points 1 through 7 below

Applications will be examined by the review committee, headed by Program Directors: Wayne Frankel, PhD and Ali Gharavi, MD, on a rolling basis with notification of funding within a month of review.

Submit application by March 30th 2018, as one single pdf, to the Program Administrator at precisionmedicine@columbia.edu

Checklist

1. Does the mouse carrying the mutation already exist? What is known about its viability, transmission and availability? Example websites to check:

  • www.informatics.jax.org
  • www.komp.org
  • www.mousephenotype.org/data/search

2. Type of mutation desired (more complex models will cost more)

  • Simple null allele (knockout)
  • Conditional knockout (lox p sites flanking exon)
  • Simple knockin (point mutation(s) only)
  • Complex knockin
  • Site-specific reporter or cre gene insertion
  • Conditional point mutation (e.g. flox-stop cassette)

3. Mouse strain background (e.g. C57BL/6J, 129/SvImJ, FVB/NJ): Are you targeting in direct zygotes or in ES cells? Some vendors may not be licensed to legally target certain mouse strains or sub-strains from other vendors. Check with your service provider on strains they use.

4. “All in” service (from initial design to receipt of proven carriers), or participate in the screening for, and development of, the mutation? Some vendors will only offer all-in service, which may be more expensive but gives the convenience of proven germline transmission and fecundity and viability of mice carrying the mutation; Others may offer a la carte services that will save out of pocket-costs but do not do the screening and initial breeding.

5. Do you already have a IACUC protocol for studying mice? Ensure the expected mice are on your protocol and funding is in place for animal housing, in synchrony with the estimated delivery date

6. We strongly recommend that you have funds to cryopreserve the strain, or have that included as an integral part of the quotation (if it is offered by the same service provider). CPMI will not pay for separate cryopreservation or for storage costs).

7. PI must have their service provider approved by ICM as a mouse vendor - this program will not pay for quarantine or re-derivation services. Please note Columbia purchasing may require sole source justification. Examples of service providers that offer mouse gene targeting (may not be approved by CU and the ICM)

  • Bioincyte
  • HICCC Transgenic Core (Columbia – in ICRC)
  • Cyagen
  • Ingenious
  • The Jackson Laboratory
  • Leveragen
  • MSKCC Mouse Genetics Core

The Vagelos Precision Medicine Pilot Grant program is made possible by the generous gift of Roy and Diana Vagelos, to the Columbia Precision Medicine Initiative, and is intended to support ground-breaking research in the field of precision medicine.

Proposals are requested for two-year pilot studies in precision medicine. Awardees will receive $100,000 per year for two years. Studies must be relevant to advancing precision medicine basic science. Examples areas include genomic data, biomarkers, clinical data, new methods of working with precision medicine data, technology development, disease mechanism studies and stem cell biology. For research with human subjects, an IRB must be in place at the time of funding.

These pilot grants are intended to support feasibility studies that will establish a basis for applying for further research funding. As such, pilot grants are intended to generate preliminary data required to produce competitive grant applications to outside funders.  

Three studies will be funded, with additional calls for proposals expected next year.

Eligibility: Applicants must have a full-time Columbia University faculty appointment at the rank of an Assistant, Associate, or Full Professor, including NYPSI and clinical faculty. Studies may involve more than one department, including collaboration between Morningside and Medical Center campuses. Preference will be given to applications including junior investigators. Applicants may apply for the Irving Institute Precision Medicine award and the Vagelos award, but may not hold both concurrently; if successful in both applicants will be able to choose their preferred award.

Budget: $100,000 per fiscal year for two years. Second year funding contingent on satisfactory progress report

Application Directions: Prepare detailed project description (2-4 page excluding references, minimum 11-point font) as follows:

• Investigators

• Background and Specific Aims

• Preliminary Findings

• Methods

• Future Plans and Direction

• Literature citations

Provide the following supporting documents:

• Statement of Facilities and other Resources

• NIH-style biographical sketch for each investigator (5-page limit)

• Budget

Submit documents by December 11th 2017, preferably as one single pdf to precisionmedicine@columbia.edu

Eligible applications submitted by the deadline will be evaluated by confidential peer reviewers. Reviewers must remain anonymous but may opt to give feedback to the applicants through the Precision Medicine office, but are not required to do so. Winning applications will be announced in February 2018. 

Questions? Email precisionmedicine@columbia.edu

Irving Institute for Clinical and Translational Research

The Precision Medicine Research Fellowship aims to create the next generation of leaders in the development and application of Precision Medicine science and methods to improve public health. This new research fellowship in precision medicine will train physicians/researchers as Postdoctoral Research Scientists to use genomics and complex clinical data to improve clinical care and clinical outcomes by tailoring prevention, screening, and medical interventions based upon individual patient characteristics.
 
Qualifications:
Applicants must have a PhD, MD, DDS, or comparable doctoral degree from an accredited domestic or foreign institution.
 
Duration:  2 years
Award Amount:  $200,000 ($100,000 per year)
Quantity:  Up to 2 per year
 
Application Deadline:  5:00pm EDT, Friday, May 18, 2018
Start Date:  July 1, 2018
 
Visit here for more information and to download an application.
 
Accelerating Discoveries Toward Better Health
irvinginstitute.columbia.edu