Tom Maniatis is the Isidore S. Edelman Professor of Biochemistry at the Columbia University Medical Center. In 2014, he was appointed Director of the Columbia’s Precision Medicine Initiative - a University-wide initiative founded by University President Lee Bollinger. In addition, he was recently named Scientific Director and Chief Executive Officer of the New York Genome Center.
Dr. Maniatis is known for pioneering the development of gene cloning technology and its application to both basic research and biotechnology. He also coauthored the definitive laboratory manual on Molecular Cloning. His research has led to fundamental advances in understanding the mechanisms of gene regulation and RNA splicing, the biochemistry of innate immunity signaling pathways, the function of single cell diversity in the nervous system, and neurodegenerative disease mechanisms.
Dr. Maniatis’ research has been recognized by many awards, including the Eli Lilly Award in Microbiology and Immunology, The Richard Lounsbery Award for Biology and Medicine (Awarded by the French and U.S National Academy of Sciences), and the 2012 Lasker-Koshland Special Achievement Award in Medical Science. He is a member of the U.S. National Academy of Science, the U.S. Academy of Medicine, and a fellow of the U.S. Academy of Arts and Sciences.
Dr. Maniatis cofounded the New York Genome Center in 2011. He is also a pioneer in the biotechnology industry, co-founding Genetics Institute in 1980, ProScript, and Acceleron. Recently Dr. Maniatis cofounded “Kallyope”, a New York city-based gut/brain axis company.
His laboratory is currently focused on molecular neuroscience, with interests in the role single cell diversity in brain wiring, and disease mechanisms in the neurodegenerative disease ALS (Lou Gehrig’s Disease). Dr. Maniatis’ laboratory manual on Molecular Cloning was instrumental in the wide dissemination of DNA cloning methods internationally for over 30 years.
Dr. Maniatis received his B.A. and MS. degrees from the University of Colorado in chemistry and biology, and his Ph.D. in molecular biology from Vanderbilt University. After postdoctoral studies at Harvard University and the Laboratory of Molecular Biology, Cambridge, England, Dr. Maniatis was a professor at the California Institute of Technology and subsequently at Harvard University.